Our history. I am 36, my husband is 39. 1st pregnancy was in 2009 after 3 IuI’s (intra uterine insemination) and clomid, but had to terminate at 15 weeks due to large enphaloceale (was a random genetic mutation)and my 2nd pregnancy with IUI was a success with a full term healthy baby boy.
I have had all the immunity checks done, my husbands sperm dna damage is within normal, fertilisation rate is good. My ovarian reserve was also checked and the level was 1.0- My specialist said that he wasn’t overly worried about the reserve for my age. I have had a hysteroscopy and all normal. I have been on various drug protocols and this last one was the long Lupron cycle with menapur.
I am writing from CapeTown, South Africa.
The exact cause of your failure cannot be known as there are still four steps your embryo has to go through in order to produce a pregnancy: embryo has to develop to blastocyst, the blastocyst has to hatch our of its shell, it then has to attach to the uterine lining and the lining has to grow around it. As of now, there is no technology that can make this happen. “Assisted hatching” is just making a defect in the shell so that the embryo can exit (hatch) more easily.
One thing that I do with my patients that is not universally accepted but done by many of us, is to use a recurrent miscarriage protocol to reduce the immune system, thinking that a heightened immune system might be at fault. For this regimen I add low dose heparin or lovenox, medrol, low dose aspirin, extra estrogen and extra progesterone (both injectable and vaginal). I don’t think that DHEA does anything so I don’t use it.
Good luck in your journey to have a second child,
Executive Medical Director
The Fertility And Gynecology Center
Monterey Bay IVF